Provision of fluorescently labelled probes for the Fluorescent in situ Hybridisation (FISH) Service in the Histopathology Dept at St James’s Hospital.

Ausschreibungsbeschreibung

Invitation to tender for the Provision of fluorescently labelled probes for the Fluorescent in situ Hybrisisation (FISH) Service in the Histopathology Dept at St James’s Hospital. The FISH service at SJH has provided a hospital and national service since 2010, helping on cancer classification and to guide patient treatment. The laboratory now requires the provision of the following fluorescently labelled ready to use probes: • MYC (8q24) Break Apart FISH probe, to detect chromosomal rearrangements involving the MYC gene on Chromosome 8q24. • t(8;14) MYC/IGH dual-fusion FISH probe, to detect reciprocal translocation involving the IGH and MYC genes. • BCL2 (18q21) Break Apart FISH probe, to detect chromosomal rearrangements involving the BCL2 gene on Chromosome 18q21. • t(14;18) IGH/BCL2 DF dual-fusion FISH probe, to detect reciprocal translocations involving the IGH and BCL2 genes. • BCL6 (3q27) Break Apart FISH probe, to detect chromosomal rearrangements involving the BCL6 gene on Chromosome 3q27. • MALT1 (18q21) Break Apart FISH probe, to detect chromosomal rearrangements involving the MALT1 gene on Chromosome 18q21. • t(11;14) CCDN1/IGH dual-fusion FISH probe, to detect reciprocal translocations involving the IGH and CCDN1 genes. • IgK-cMYC dual-fusion FISH probe, to detect reciprocal translocation involving the IGK and MYC genes. • IgL-cMYC dual-fusion FISH probe, to detect reciprocal translocation involving the IGL and MYC genes. • DUSP22-IRF4 Break Apart FISH probe, to detect chromosomal rearrangements involving the DUSP22 or IRF4 gene. • TP63 Break Apart FISH probe, to detect chromosomal rearrangements involving the TP63 gene. • 11q gain-loss FISH probe, to detect 11q Aberration. • ALK (2p23) Break Apart FISH probe, to detect chromosomal rearrangements involving the ALK gene on Chromosome 2p23. • ROS1 (6q22) Break Apart FISH probe, to detect chromosomal rearrangements involving the ROS1 gene on Chromosome 6q22. • MDM2/CEN12 Amplification FISH probe, to detect 11q Aberration.